Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 17/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069914 | 0.89 | ALK (0.53) | PDPK1ALK | |
| SCHEMBL3591973 | 0.86 | PDPK1 (0.49) | PDPK1ALK | |
| SCHEMBL9284633 | 0.79 | ALK (0.56) | PDPK1ALK | |
| SCHEMBL3596086 | 0.79 | ALK (0.52) | PDPK1ALKTNIK | |
| SCHEMBL9887914 | 0.78 | PDPK1 (0.52) | PDPK1ALK | |
| SCHEMBL9284637 | 0.78 | ALK (0.50) | PDPK1ALKTNIK | |
| SCHEMBL28481416 | 0.77 | PDPK1 (0.51) | PDPK1ALK | |
| SCHEMBL9887923 | 0.76 | ALK (0.48) | PDPK1ALK | |
| SCHEMBL9282702 | 0.75 | PDPK1 (0.47) | PDPK1ALKTNIK | |
| SCHEMBL3833314 | 0.75 | ALK (0.52) | PDPK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081937-A2 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008051805-A2 | TRIAZOLO-PYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |