Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | DAO | P14920 | 1/20 | 1.00 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 1.00 |
| ▸ | CES2 | O00748 | 3/20 | 0.78 |
| ▸ | CES1 | P23141 | 3/20 | 0.78 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA3 | P07451 | 2/20 | 0.58 |
| ▸ | CA4 | P22748 | 2/20 | 0.58 |
| ▸ | CA6 | P23280 | 2/20 | 0.58 |
| ▸ | CA5A | P35218 | 2/20 | 0.58 |
| ▸ | CA7 | P43166 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.58 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL4591761 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL149318 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL9751726 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL137419 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL975929 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL11602198 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL3966600 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL976149 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL7719037 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL2458489 | 1.00 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 746 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230263817-A1 | HIGH DOSE NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) PRECURSOR REGIMENS FOR REDUCTION OF INFLAMMATION IN HUMAN PATIENTS WITH PREEXISTING INFLAMMATION | UNIVERSITY OF WASHINGTON (US) | 2023-08-24 | — | — | US | claimed |
| EP-3728187-B1 | PROCESS FOR PREPARING A POWDERY ORGANIC PEROXIDE FORMULATION | NOURYON CHEMICALS INT BV (NL) | 2022-06-22 | — | — | EP | claimed |
| CN-111557913-B | Nano photosensitive compound targeting epileptic cells and regulation and control detection system | 中国科学院空天信息创新研究院 | 2022-05-31 | — | — | CN | claimed |
| EP-3999051-A2 | USE OF A BENZOATE CONTAINING COMPOSITION TO TREAT NEURODEGENERATIVE DISORDERS | Rush University Medical Center (US) | 2022-05-25 | — | — | EP | claimed |
| US-20220125814-A1 | CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2022-04-28 | — | — | US | claimed |
| CN-109647354-B | Application of modified fiber in purifying VOC | 郑州大学 | 2021-12-31 | — | — | CN | claimed |
| EP-3625290-B1 | MULTI-LAYER ANTI-FOG COMPOSITIONS AND PROCESSES FOR MAKING SAME | CELANESE INT CORP (US) | 2021-12-22 | — | — | EP | claimed |
| CN-113811287-A | Low VOC multifunctional additives for improving aqueous polymer film properties | 艾默罗德卡拉玛化学品公司 | 2021-12-17 | — | — | CN | claimed |
| CN-113690429-A | Carbon-coated graphene/metal oxide composite material and preparation method thereof | 武汉立承科技有限公司 | 2021-11-23 | — | — | CN | claimed |
| US-10960340-B2 | Composition and system for gas storage | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2021-03-30 | — | — | US | claimed |
| US-5334311-A | Resolution of optical isomers | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-02 | — | — | US | claimed |
| EP-0411303-B1 | Halogen-free melt processable silicone-imide wire coating compositions having low smoke values | GEN ELECTRIC (US) | 1994-01-12 | — | — | EP | claimed |
| US-RE34457-E | For optical and geometric isomers comprising optionally substituted cellulose tribenzoate supported on porous carrier | DAICEL CHEMICAL INDUSTRIES, INC. (JP) | 1993-11-30 | — | — | US | claimed |
| US-5032277-A | Chromatography | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1991-07-16 | — | — | US | claimed |
| EP-0354323-A2 | Antidiabetic phosphates | AMERICAN CYANAMID COMPANY (US) | 1990-02-14 | — | — | EP | claimed |
| US-4830752-A | OPTICAL RESOLUTION | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1989-05-16 | — | — | US | claimed |
| US-4818394-A | CELLULOSE TRIBENZOATES ON POROUS CARRIER | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-04 | — | — | US | claimed |
| EP-0161118-B1 | FLEXIBLE POLYVINYLIDENE FLUORIDE COMPOSITIONS, AND THEIR USE, ESPECIALLY IN MAKING FLEXIBLE TUBES | Institut Français du Pétrole (FR) | 1988-09-14 | — | — | EP | claimed |
| US-4745026-A | FINE PARTICLE SOLID PLASTICIZER | MITSUBISHI PAPER MILLS, LTD. (JP) | 1988-05-17 | — | — | US | claimed |
| EP-0161118-A1 | Flexible polyvinylidene fluoride compositions, and their use, especially in making flexible tubes | Institut Français du Pétrole (FR) | 1985-11-13 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230263817-A1 | HIGH DOSE NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) PRECURSOR REGIMENS FOR REDUCTION OF INFLAMMATION IN HUMAN PATIENTS WITH PREEXISTING INFLAMMATION | NAMPT, NNT, NQO1 | TSHR 3727/4885DAO 2760/4885NAPRT 5/4885 |
| US-20220125814-A1 | CANCER COMBINATION THERAPIES UTILIZING A NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITOR IN COMBINATION WITH A NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY PRECURSOR | NAMPT, NADK, NNT | TSHR 4201/4885DAO 3842/4885NAPRT 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.