Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 4/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415474 | 1.00 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL2929834 | 1.00 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL2926494 | 1.00 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL3415478 | 1.00 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL1339459 | 1.00 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL2446730 | 0.92 | NR1H2 (0.40) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL10151427 | 0.92 | NR1H2 (0.40) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL496604 | 0.92 | NR1H2 (0.40) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL24909276 | 0.88 | NR1H2 (0.53) | NR1H2CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL21554826 | 0.88 | NR1H2 (0.53) | NR1H2CHRM2CHRM1CHRM3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008038251-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-04-03 | — | — | WO | disclosed |