Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.50 |
| ▸ | CCND1 | P24385 | 5/20 | 0.50 |
| ▸ | CCND2 | P30279 | 5/20 | 0.50 |
| ▸ | CCND3 | P30281 | 5/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264282 | 0.86 | CDK4 (0.52) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL2320862 | 0.85 | EGFR (0.43) | CDK4CCND1CCND2CCND3PDE3B | |
| SCHEMBL748173 | 0.77 | CCND3 (0.49) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL29979953 | 0.76 | JAK1 (0.50) | JAK1TYK2 | |
| SCHEMBL16416249 | 0.76 | MAPK8 (0.48) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL10346428 | 0.74 | CDK4 (0.61) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL20400864 | 0.73 | SYK (0.51) | CDK4CCND1CCND2CCND3MAPK8 | |
| SCHEMBL30950984 | 0.72 | BRAF (0.46) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL16993339 | 0.72 | CDK4 (0.51) | CDK4CCND1CCND2CCND3PDE3B | |
| SCHEMBL17910166 | 0.72 | MAPK8 (0.54) | CDK4CCND1CCND2CCND3PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751155-B1 | SUBSTITUTED AZACHINAZOLINES HAVING AN ANTIVIRAL ACTION | BAYER HEALTHCARE AG (DE) | 2009-01-07 | — | — | EP | disclosed |