Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30660251 | 0.83 | CYP1A2 (0.44) | ALDH1A1MAPTMEN1CYP1A2KMT2A | |
| SCHEMBL6857601 | 0.83 | HTT (0.57) | LMNAGAAHTTALDH1A1MAPT | |
| SCHEMBL7236821 | 0.83 | HTT (0.57) | LMNAGAAHTTALDH1A1MAPT | |
| SCHEMBL1294031 | 0.83 | HTT (0.57) | LMNAGAAHTTALDH1A1MAPT | |
| SCHEMBL6690257 | 0.82 | ATM (0.57) | LMNACYP3A4KMT2AHPGDPOLB | |
| SCHEMBL22950648 | 0.82 | ATM (0.57) | LMNACYP3A4KMT2AHPGDPOLB | |
| Hydrochloric Acid SCHEMBL1294029 | 0.81 | HTT (0.56) | LMNAGAAHTTALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1294033 | 0.81 | HTT (0.56) | LMNAGAAHTTALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6165654 | 0.81 | ATM (0.55) | LMNACYP3A4KMT2AHPGDPOLB | |
| SCHEMBL22445526 | 0.80 | SLC1A3 (0.48) | ALDH1A1MAPTMEN1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| CN-1905884-A | Pyrazole derivatives as inhibitors of receptor tyrosyne kinases | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |