Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.71 |
| ▸ | EGLN2 | Q96KS0 | 15/20 | 0.58 |
| ▸ | THRA | P10827 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181308 | 0.90 | EGLN1 (0.72) | EGLN1EGLN2 | |
| SCHEMBL4075987 | 0.88 | EGLN1 (0.72) | EGLN1EGLN2 | |
| SCHEMBL8141355 | 0.87 | EGLN1 (0.71) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523399 | 0.87 | EGLN1 (0.71) | EGLN1EGLN2THRATHRB | |
| SCHEMBL8146957 | 0.85 | EGLN1 (0.69) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523170 | 0.83 | EGLN1 (0.84) | EGLN1EGLN2 | |
| SCHEMBL30274462 | 0.83 | EGLN1 (0.84) | EGLN1EGLN2 | |
| SCHEMBL522758 | 0.83 | EGLN1 (0.84) | EGLN1EGLN2THRATHRB | |
| SCHEMBL522721 | 0.83 | EGLN1 (0.84) | EGLN1EGLN2 | |
| SCHEMBL3780901 | 0.83 | EGLN1 (0.87) | EGLN1EGLN2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |