Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309601 | 0.79 | PIK3CA (0.60) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL1310548 | 0.76 | ATR (0.58) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL4565350 | 0.74 | PIK3CA (0.49) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL18193255 | 0.74 | PIK3CA (0.76) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL1309278 | 0.74 | PIK3CA (0.77) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL17361013 | 0.73 | PIK3CD (0.39) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL17014780 | 0.72 | AR (1.00) | ARPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL1864435 | 0.71 | PIK3CA (0.74) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL16639125 | 0.71 | PIK3CD (0.66) | PIK3CAPIK3CBMTORPIK3CD | |
| SCHEMBL1857546 | 0.71 | PIK3CA (1.00) | PIK3CAPIK3CBMTORPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | claimed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | claimed |
| CN-102970868-A | Treatment of cancers having K-RAS mutations | CURIS INC | 2013-03-13 | — | — | CN | disclosed |
| CN-102341108-A | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY | CURIS INC | 2012-02-01 | — | — | CN | disclosed |
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |
| EP-1812445-A1 | PHARMACEUTICAL COMPOUNDS | Piramed Limited (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006046031-A1 | PHARMACEUTICAL COMPOUNDS | PIRAMED LIMITED (GB) | 2006-05-04 | — | — | WO | disclosed |