Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.74 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.74 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 10/20 | 0.47 |
| ▸ | AKT1 | P31749 | 7/20 | 0.46 |
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MARK1 | Q9P0L2 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078453 | 0.92 | NTRK1 (0.62) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4076606 | 0.91 | PDGFRB (0.62) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4081562 | 0.89 | PDGFRB (0.63) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4080809 | 0.89 | NTRK1 (0.58) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4076725 | 0.88 | NTRK1 (0.58) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL1942082 | 0.87 | NTRK1 (0.69) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL1941535 | 0.87 | NTRK1 (0.77) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4081524 | 0.85 | NTRK1 (1.00) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4081125 | 0.85 | PDGFRB (0.62) | NTRK1NTRK3NTRK2KCNH2PDGFRB | |
| SCHEMBL4076152 | 0.85 | PDGFRB (0.62) | NTRK1NTRK3NTRK2KCNH2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595325-B2 | Substituted pyrrolo[2,3-d]pyrimidine derivatives useful in cancer treatment | PFIZER INC. (US) | 2009-09-29 | — | — | US | disclosed |
| EP-1773836-A1 | PYRROLOPYRIMIDINE DERIVATIVES USEFUL IN CANCER TREATMENT | Pfizer Products Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20060035912-A1 | Pyrrolopyrimidine derivatives useful in cancer treatment | PFIZER INC | 2006-02-16 | — | — | US | disclosed |
| WO-2005116035-A1 | PYRROLOPYRIMIDINE DERIVATIVES USEFUL IN CANCER TREATMENT | PFIZER PRODUCTS INC. (US) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035912-A1 | Pyrrolopyrimidine derivatives useful in cancer treatment | TP53, DPYD, CCNT1 | NTRK1 3916/4885NTRK3 2158/4885NTRK2 4246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.