Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.78 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | BMP1 | P13497 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017943 | 0.92 | CXCR4 (0.67) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL29580087 | 0.88 | CXCR4 (1.00) | CXCR4MCHR1PADI4PADI2 | |
| SCHEMBL6017976 | 0.87 | CXCR4 (0.61) | CXCR4EPHX2METAP2METAP1MCHR1 | |
| SCHEMBL6652983 | 0.85 | CXCR4 (0.70) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL6652769 | 0.85 | CXCR4 (0.74) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL6656486 | 0.85 | CXCR4 (0.74) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL6656081 | 0.85 | CXCR4 (0.74) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL6654961 | 0.85 | CXCR4 (0.74) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL6658566 | 0.84 | CXCR4 (0.71) | CXCR4EPHX2METAP2METAP1CASR | |
| SCHEMBL6653580 | 0.84 | CXCR4 (0.72) | CXCR4METAP2METAP1CASRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098215-B2 | Nitrogenous compounds and antiviral drugs containing the same | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2006-08-29 | — | — | US | claimed |
| EP-1608318-A4 | CXCR4 ANTAGONISTS AND METHODS OF THEIR USE | UNIV EMORY (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090036416-A1 | Novel CXCR4 Antagonist and Use Thereof | KYOTO UNIVERSITY (JP) | 2009-02-05 | — | — | US | disclosed |
| US-20090036416-A1 | Novel CXCR4 Antagonist and Use Thereof | KYOTO UNIVERSITY (JP) | 2009-02-05 | — | — | US | disclosed |
| US-7098215-B2 | Nitrogenous compounds and antiviral drugs containing the same | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2006-08-29 | — | — | US | disclosed |
| EP-1608318-A2 | CXCR4 ANTAGONISTS AND METHODS OF THEIR USE | Emory University (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004087068-A2 | CXCR4 ANTAGONISTS AND METHODS OF THEIR USE | EMORY UNIVERSITY (US) | 2004-10-14 | — | — | WO | disclosed |
| US-20040157818-A1 | Cxcr4-antagonistic drugs composed of nitrogen-containing compound | KUREHA CORPORATION (JP) | 2004-08-12 | — | — | US | disclosed |
| US-20040092556-A1 | Nitrogenous compounds and antiviral drugs containing the same | KUREHA CORPORATION (JP) | 2004-05-13 | — | — | US | disclosed |
| EP-1273571-A1 | NITROGENOUS COMPOUNDS AND ANTIVIRAL DRUGS CONTAINING THE SAME | Kureha Chemical Industry Co., Ltd. (JP) | 2003-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092556-A1 | Nitrogenous compounds and antiviral drugs containing the same | NSUN2, ZC3HAV1L, PNP | CXCR4 2185/4885EPHX2 3438/4885METAP2 1763/4885 |
| US-20040157818-A1 | Cxcr4-antagonistic drugs composed of nitrogen-containing compound | CXCR4, CXCR1, CXCR2 | CXCR4 1/4885EPHX2 2096/4885METAP2 4172/4885 |
| US-20090036416-A1 | Novel CXCR4 Antagonist and Use Thereof | CXCR4, CXCR1, CXCL12 | CXCR4 1/4885EPHX2 4289/4885METAP2 1042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.