Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 11/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.74 |
| ▸ | ABL1 | P00519 | 11/20 | 0.64 |
| ▸ | BCR | P11274 | 8/20 | 0.64 |
| ▸ | PRKCA | P17252 | 3/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 6/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | PRKCH | P24723 | 1/20 | 0.56 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087636 | 0.90 | ABL1 (0.61) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL3660909 | 0.90 | ABL1 (0.70) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL4087634 | 0.89 | PDGFRA (0.58) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL13996782 | 0.85 | PDGFRA (0.78) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL4084979 | 0.85 | PDGFRB (0.82) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL4092111 | 0.84 | ABL1 (0.78) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL4082814 | 0.83 | ABL1 (0.65) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL4082832 | 0.82 | ABL1 (0.77) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL23265149 | 0.81 | ABL1 (0.75) | PDGFRAPDGFRBABL1BCRPRKCA | |
| SCHEMBL29873323 | 0.81 | ABL1 (0.75) | PDGFRAPDGFRBABL1BCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065734-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | 4SC AG (DE) | 2011-03-17 | — | — | US | disclosed |
| EP-2060565-A1 | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases | 4SC AG (DE) | 2009-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065734-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | HDAC1, HDAC11, MAP2K2 | PDGFRA 2510/4885PDGFRB 2334/4885ABL1 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.