Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | APOB | P04114 | 6/20 | 0.43 |
| ▸ | MTTP | P55157 | 6/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289943 | 0.93 | POLB (0.44) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289178 | 0.92 | EPHX2 (0.45) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3288519 | 0.91 | SMO (0.47) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3288509 | 0.91 | NTRK1 (0.50) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289550 | 0.90 | EPHX2 (0.41) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289783 | 0.90 | SMO (0.46) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289639 | 0.90 | SLC5A7 (0.43) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289955 | 0.90 | EPHX2 (0.43) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289726 | 0.90 | NTRK1 (0.43) | EPHX2APOBMTTPNTRK1KCNH2 | |
| SCHEMBL3289653 | 0.90 | EPHX2 (0.42) | EPHX2FAAHCFDKLK7PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753721-B1 | AROYL-O-PIPERIDINE DERIVATIVES FOR THE TREATMENT OF DIABETES-RELATED PROBLEMS | MERCK PATENT GMBH (DE) | 2009-08-05 | — | — | EP | claimed |