Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641800 | 0.84 | PLK1 (0.53) | RARBPLK1PPARGPPARATAOK3 | |
| SCHEMBL4079706 | 0.83 | RARB (0.47) | RARBPLK1TP53TSHRPLA2G4B | |
| SCHEMBL642400 | 0.81 | RARB (0.43) | RARBPLK1TP53TSHRPPARG | |
| SCHEMBL643865 | 0.81 | RARB (0.42) | RARBPLK1TP53TSHRPPARG | |
| SCHEMBL642610 | 0.79 | PLK1 (0.51) | RARBPLK1PPARGPPARA | |
| SCHEMBL641397 | 0.77 | MCHR1 (0.48) | RARBPLK1TP53TSHRPPARG | |
| SCHEMBL642508 | 0.76 | NR1H4 (0.54) | PLK1TP53 | |
| SCHEMBL643775 | 0.75 | MCHR1 (0.45) | RARBTP53TSHRPPARGPPARA | |
| SCHEMBL641374 | 0.74 | RARB (0.41) | RARBTP53TSHRPPARGPPARA | |
| SCHEMBL643453 | 0.73 | RARB (0.41) | RARBTP53TSHRPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057173-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | Novartis AG (CH) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008022771-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2008-02-28 | — | — | WO | disclosed |