Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | LITAF | Q99732 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 10/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.31 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087715 | 0.88 | PLK1 (0.41) | PLK1BRD4PLK2PLK3PIP4K2A | |
| SCHEMBL1203249 | 0.88 | TTK (0.38) | TTKTNFLITAFPDE4BPDE4D | |
| SCHEMBL18261942 | 0.80 | PLK1 (0.48) | PLK1BRD4TAF1PLK2PLK3 | |
| SCHEMBL4516187 | 0.80 | PLK1 (0.48) | PLK1BRD4TAF1PLK2PLK3 | |
| SCHEMBL4084476 | 0.79 | PLK1 (0.39) | TTKPLK1BRD4PLK2PLK3 | |
| SCHEMBL13846165 | 0.78 | PLK1 (0.39) | TTKPLK1BRD4PLK2PLK3 | |
| SCHEMBL3994540 | 0.78 | PLK1 (0.38) | TTKPLK1BRD4PLK2HSD11B1 | |
| SCHEMBL15222137 | 0.77 | PSEN1 (0.50) | TTKPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1559270 | 0.77 | PLK1 (0.41) | TTKTNFLITAFPDE4BPDE4D | |
| SCHEMBL4076490 | 0.76 | KDM4E (0.35) | TNFLITAFPDE4BPDE4DPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517873-B2 | Substituted pyrimidodiazepines | HOFFMAN-LA ROCHE INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | PLK1, CCNI, CDK1 | TTK 220/4885TNF 4684/4885LITAF 1961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.