Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 12/20 | 0.84 |
| ▸ | RAD52 | P43351 | 2/20 | 0.83 |
| ▸ | BRD4 | O60885 | 11/20 | 0.75 |
| ▸ | BRDT | Q58F21 | 9/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.66 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.66 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.65 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.65 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | FES | P07332 | 2/20 | 0.64 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.64 |
| ▸ | CLK2 | P49760 | 2/20 | 0.64 |
| ▸ | NEK2 | P51955 | 2/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.64 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669790 | 0.93 | PLK1 (0.97) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL619257 | 0.91 | PLK1 (1.00) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL1204202 | 0.91 | PLK1 (0.94) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL31307909 | 0.91 | RAD52 (1.00) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL17706070 | 0.91 | RAD52 (1.00) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL3543386 | 0.91 | RAD52 (1.00) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL4076281 | 0.90 | PLK1 (0.68) | PLK1RAD52BRD4BRDTPLK3 | |
| SCHEMBL1203631 | 0.90 | PLK1 (0.84) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL3542911 | 0.90 | RAD52 (0.96) | PLK1RAD52BRD4BRDTALK | |
| SCHEMBL4079449 | 0.89 | PLK1 (0.85) | PLK1RAD52BRD4BRDTALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517873-B2 | Substituted pyrimidodiazepines | HOFFMAN-LA ROCHE INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517873-B2 | Substituted pyrimidodiazepines | HOFFMAN-LA ROCHE INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-7517873-B2 | Substituted pyrimidodiazepines | HOFFMAN-LA ROCHE INC. (US) | 2009-04-14 | — | — | US | disclosed |
| WO-2008113711-A1 | SUBSTITUTED PYRIMIDODIAZEPINES USEFUL AS PLK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-25 | — | — | WO | disclosed |
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | US | disclosed |
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | US | disclosed |
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | PLK1, CCNI, CDK1 | PLK1 1/4885RAD52 2632/4885BRD4 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.