Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537758 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4408892 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4537756 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4079998 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4408888 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4110092 | 0.83 | IDO1 (0.52) | HTR2CHTR2AHTR2BIDO1GAA | |
| SCHEMBL4107338 | 0.82 | HTR2C (0.54) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4054091 | 0.82 | HTR2C (0.54) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4096972 | 0.82 | HTR2C (0.54) | HTR2CHTR2AHTR2BIDO1LMNA | |
| SCHEMBL4097294 | 0.80 | HTR2C (0.53) | HTR2CHTR2AHTR2BIDO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057119-A1 | 3- (IH-INDOL- 3-YDINDAN-1-YLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | H. Lundbeck A/S (DK) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008025361-A1 | 3-(1H-INDOL-3-YL) INDAN-1-YLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | H. LUNDBECK A/S (DK) | 2008-03-06 | — | — | WO | disclosed |