Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.78 |
| ▸ | AKT1 | P31749 | 2/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.69 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.69 |
| ▸ | PFKP | Q01813 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.69 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.69 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080654 | 1.00 | MTOR (0.78) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL2901002 | 0.88 | MTOR (1.00) | MTORAKT1KCNH2 | |
| SCHEMBL1218929 | 0.86 | MTOR (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL290661 | 0.86 | MTOR (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL2903023 | 0.85 | MTOR (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL26062596 | 0.85 | MTOR (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL289851 | 0.85 | AKT1 (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL18434073 | 0.85 | AKT1 (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL10224929 | 0.85 | MTOR (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL393754 | 0.85 | AKT1 (1.00) | MTORAKT1PIK3CDPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057156-A1 | 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Kudos Pharmaceuticals Limited (GB) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023161-A1 | 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-02-28 | — | — | WO | disclosed |