Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 9/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980166 | 1.00 | PTGER4 (0.39) | PTGER4PTGER3PTGER2TBXA2RCYP4F2 | |
| SCHEMBL4300863 | 0.93 | PTGER4 (0.35) | PTGER4PTGER3PTGER2TBXA2RCYP4F2 | |
| SCHEMBL3984251 | 0.93 | PTGER4 (0.35) | PTGER4PTGER3PTGER2TBXA2RCYP4F2 | |
| SCHEMBL4299817 | 0.89 | PTGER4 (0.46) | PTGER4PTGER3PTGER2TBXA2RPTGER1 | |
| SCHEMBL4088157 | 0.89 | PTGER4 (0.46) | PTGER4PTGER3PTGER2TBXA2RPTGER1 | |
| SCHEMBL4107654 | 0.84 | PTGER4 (0.52) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL4794136 | 0.84 | PTGER4 (0.52) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL4303788 | 0.83 | PTGER4 (0.40) | PTGER4PTGER3PTGER2TBXA2R | |
| SCHEMBL4094060 | 0.83 | PTGER4 (0.40) | PTGER4PTGER3PTGER2TBXA2R | |
| SCHEMBL4094057 | 0.83 | PTGER4 (0.40) | PTGER4PTGER3PTGER2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912957-A4 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD (CA) | 2009-05-13 | — | — | EP | claimed |
| EP-1912957-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | Merck Frosst Canada Ltd. (CA) | 2008-04-23 | — | — | EP | claimed |
| WO-2007014462-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2007-02-08 | — | — | WO | claimed |