Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136038 | 0.98 | CYP2D6 (0.59) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL8199005 | 0.88 | OPRL1 (0.62) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL28176684 | 0.82 | CYP2D6 (0.56) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL6378751 | 0.82 | CYP2D6 (0.57) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL5242779 | 0.81 | OPRL1 (0.67) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL11353776 | 0.81 | CYP2D6 (0.59) | CYP2D6OPRL1ALDH1A1CYP3A4TSHR | |
| SCHEMBL6377977 | 0.81 | CYP2D6 (0.55) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL30889332 | 0.80 | CYP2D6 (0.54) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL10750648 | 0.80 | POLB (0.68) | CYP2D6OPRL1POLBALDH1A1CYP3A4 | |
| SCHEMBL3493144 | 0.80 | CYP2D6 (0.54) | CYP2D6OPRL1POLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037919-A2 | METHOD OF USING SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY | SCHERING CORPORATION (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005266-A2 | METHOD OF USING SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY | SCHERING CORPORATION (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20080004286-A1 | Method of Using Substituted Piperidines that Increase P53 Activity | SCHERING CORPORATION | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004286-A1 | Method of Using Substituted Piperidines that Increase P53 Activity | TP53, MDM2, TP53BP1 | SIGMAR1 4563/4885CYP2D6 3444/4885OPRL1 4256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.