Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 9/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 14/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 10/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGFR | P43088 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255207 | 0.80 | PTGDR (0.42) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL1254584 | 0.79 | PDE2A (0.55) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL1255659 | 0.79 | PDE2A (0.55) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL11918206 | 0.78 | PDE2A (0.44) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL1900707 | 0.78 | PTGDR (0.41) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL1903294 | 0.78 | PTGDR (0.41) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL1255227 | 0.77 | PDE2A (0.43) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL1255632 | 0.76 | PDE2A (0.49) | PDE2APTGDRTBXA2RPTGER1PTGER4 | |
| SCHEMBL5424892 | 0.74 | PTGDR (0.52) | PDE2APTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL1255223 | 0.73 | PDE2A (0.54) | PDE2APTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116244-A1 | Method of treating atherosclerosis, dyslipidemias and related conditions | Merck & Co., Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-1874301-A4 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1874301-A1 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113150-A1 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2006-10-26 | — | — | WO | disclosed |