Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.46 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.40 |
| ▸ | ATR | Q13535 | 9/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 9/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 9/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083395 | 0.89 | PIK3CA (0.56) | PIK3CAPIK3CDMTOR | |
| SCHEMBL11898406 | 0.80 | PIK3CA (0.65) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3608628 | 0.80 | PIK3CA (0.58) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3592900 | 0.80 | PIK3CA (0.65) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3596960 | 0.77 | PIK3CA (0.62) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3588167 | 0.74 | PIK3CA (0.68) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3595284 | 0.74 | PIK3CA (0.67) | PIK3CAPIK3CDMTOR | |
| SCHEMBL13970152 | 0.74 | PIK3CA (0.60) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3601147 | 0.73 | PIK3CA (0.62) | PIK3CAPIK3CDMTOR | |
| SCHEMBL4201757 | 0.73 | PIK3CA (0.60) | PIK3CAPIK3CDMTORCHEK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |