Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Doxycycline Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 known ✓ | P09237 | 1/20 | 0.68 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.68 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.70 |
| ▸ | USP2 | O75604 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MMP2 | P08253 | 1/20 | 0.68 |
| ▸ | MMP3 | P08254 | 1/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 7/20 | 0.65 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxycycline Anhydrous SCHEMBL29947847 | 1.00 | TDP1 (0.70) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL40836 | 1.00 | TDP1 (0.70) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL1200549 | 1.00 | TDP1 (0.70) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL8709954 | 1.00 | TDP1 (0.70) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL29151798 | 0.99 | TDP1 (0.69) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL497165 | 0.99 | TDP1 (0.69) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL497163 | 0.99 | TDP1 (0.69) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL229272 | 0.99 | TDP1 (0.69) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL8709949 | 0.99 | TDP1 (0.69) | TDP1KDM4EL3MBTL1USP2HSD17B10 | |
| Doxycycline Anhydrous SCHEMBL17747966 | 0.99 | TDP1 (0.69) | TDP1KDM4EL3MBTL1USP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4607 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119950523-B | Doxycycline hydrochloride and clavulanate potassium powder for aquatic products and preparation method and application thereof | YANGTZE RIVER FISHERIES RESEARCH INSTITUTE CHINESE ACADEMY OF FISHERY SCIENCES (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122071006-A | Urea modified Bi2O3/g-C3N4Heterojunction catalyst and preparation method and application thereof | 武汉纺织大学 | 2026-05-22 | — | — | CN | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| CN-120131674-A | Florfenicol-doxycycline compound preparation and preparation method thereof | 杭州上昵生物医药研发有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120131564-A | Doxycycline hydrochloride for injection and preparation method thereof | 浙江华海药业股份有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120053598-A | Doxycycline hydrochloride and colistin sulfate injection and preparation method thereof | 中国农业大学 | 2025-05-30 | — | — | CN | claimed |
| CN-119950523-A | Doxycycline hydrochloride and clavulanate potassium powder for aquatic products and preparation method and application thereof | 中国水产科学研究院长江水产研究所 | 2025-05-09 | — | — | CN | claimed |
| CN-118039027-B | Doxycycline hydrochloride wastewater treatment method based on cyclic neural network | 江苏医药职业学院 | 2025-05-09 | — | — | CN | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5780049-A | Enhanced skin penetration system for improved topical delivery of drugs | RICHARDSON-VICKS INC. (US) | 1998-07-14 | — | — | US | claimed |
| EP-0271374-B1 | AQUEOUS ANTIBIOTIC COMPOSITION FOR VETERINARY USE | SO.GE.VAL S.A. (FR) | 1992-01-29 | — | — | EP | claimed |
| US-4693997-A | CARRAGEENAN AND DOXYCYCLINE | KABIVITRUM AB (SE) | 1987-09-15 | — | — | US | claimed |
| EP-0079928-B1 | TABLETS WHICH DO NOT DAMAGE THE OESOPHAGUS | Orion-yhtymä Oy (FI) | 1986-04-16 | — | — | EP | claimed |
| EP-0091409-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING CARRAGEEN | KabiVitrum AB (SE) | 1986-02-05 | — | — | EP | claimed |
| EP-0091409-A1 | Pharmaceutical compositions containing carrageen | KabiVitrum AB (SE) | 1983-10-12 | — | — | EP | claimed |
| EP-0079928-A1 | TABLETS WHICH DO NOT DAMAGE THE OESOPHAGUS. | ORION YHTYMAE OY (FI) | 1983-06-01 | — | — | EP | claimed |
| WO-1982004191-A1 | TABLETS WHICH DO NOT DAMAGE THE OESOPHAGUS | MARTTILA ESKO VEIKKO | 1982-12-09 | — | — | WO | claimed |
| US-3957980-A | INJECTABLE ANTIBIOTICS | PFIZER INC. (US) | 1976-05-18 | — | — | US | claimed |