Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147970 | 0.93 | KMT2A (0.32) | KMT2AMEN1KDM4EGAAMAPT | |
| SCHEMBL13100055 | 0.90 | KMT2A (0.31) | KMT2AMEN1KDM4EMAPT | |
| SCHEMBL1343276 | 0.88 | MAPT (0.36) | KMT2AMEN1KDM4EGAAMAPT | |
| SCHEMBL14618681 | 0.86 | MEN1 (0.32) | KMT2AMEN1 | |
| SCHEMBL1148541 | 0.85 | KDM4E (0.32) | KDM4EGAAMAPT | |
| SCHEMBL443435 | 0.85 | HSP90AA1 (0.35) | KMT2AMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL13108814 | 0.83 | — | — | |
| SCHEMBL14618676 | 0.82 | MAPT (0.34) | KMT2AMEN1KDM4EGAAMAPT | |
| SCHEMBL14618523 | 0.79 | CNR2 (0.31) | KMT2AGAA | |
| SCHEMBL1344009 | 0.78 | HCRTR1 (0.36) | KMT2AMEN1KDM4EMAPTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |