Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.69 |
| ▸ | RAD52 | P43351 | 2/20 | 0.68 |
| ▸ | TTK | P33981 | 4/20 | 0.61 |
| ▸ | BRD4 | O60885 | 8/20 | 0.59 |
| ▸ | BRDT | Q58F21 | 8/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203517 | 0.91 | PLK1 (0.81) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL3667826 | 0.91 | PLK1 (0.79) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL4079449 | 0.90 | PLK1 (0.85) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL3673685 | 0.90 | RAD52 (0.82) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL4076281 | 0.88 | PLK1 (0.68) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL1675607 | 0.85 | PLK1 (0.69) | PLK1RAD52BRD4BRDT | |
| SCHEMBL3539750 | 0.85 | PLK1 (0.79) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL3669258 | 0.85 | PLK1 (0.67) | PLK1RAD52TTKBRD4BRDT | |
| SCHEMBL1204202 | 0.84 | PLK1 (0.94) | PLK1RAD52BRD4BRDTPLK3 | |
| SCHEMBL3540809 | 0.84 | PLK1 (0.74) | PLK1RAD52TTKBRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517873-B2 | Substituted pyrimidodiazepines | HOFFMAN-LA ROCHE INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | PLK1, CCNI, CDK1 | PLK1 1/4885RAD52 2632/4885TTK 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.