SCHEMBL4086930

SCHEMBL4086930

N#Cc1cc(C#N)cc(Oc2c(Cl)ccc(CC(=O)O)c2F)c1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
CAMK2A Q9UQM7 3/20 0.41
THRA P10827 2/20 0.38
THRB P10828 2/20 0.38
RORC P51449 1/20 0.38
MRGPRX4 Q96LA9 1/20 0.35
CXCL8 P10145 1/20 0.35
RXRA P19793 1/20 0.34
RXRG P48443 1/20 0.34
EPAS1 Q99814 2/20 0.34
KCNH2 Q12809 2/20 0.34
CHRM1 P11229 1/20 0.34
HTR2A P28223 1/20 0.34
FFAR1 O14842 1/20 0.33
MEP1B Q16820 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1344613 0.94 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL16175471 0.92 CYP3A4 (0.46) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL3982722 0.92 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL3976283 0.90 CYP3A4 (0.50) CYP3A4CYP2C9CYP2C19RORCMRGPRX4
SCHEMBL16175564 0.90 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL16175554 0.86 KCNH2 (0.41) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL16175717 0.85 CYP3A4 (0.38) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL16175589 0.85 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19CAMK2ATHRA
SCHEMBL1342509 0.85 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19RORCEPAS1
SCHEMBL1343826 0.85 CYP3A4 (0.55) CYP3A4CYP2C9CYP2C19RORCEPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2057125-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. Hoffmann-Roche AG (CH) 2009-05-13 EP disclosed
WO-2008019968-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2008-02-21 WO disclosed