Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 10/20 | 0.55 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087694 | 0.79 | PDK2 (0.50) | POLR1AKDM4EHSD17B10PDK2KCNH2 | |
| SCHEMBL3890307 | 0.74 | PDK2 (0.50) | PARP1KDM4EHSD17B10PDK2KCNH2 | |
| SCHEMBL14430692 | 0.73 | KMT2A (0.61) | SMYD2PARP1KDM4EHSD17B10KCNH2 | |
| SCHEMBL13164061 | 0.73 | NPSR1 (0.59) | POLR1ANPSR1 | |
| SCHEMBL28598516 | 0.72 | NPSR1 (0.56) | POLR1ASMYD2KCNH2NPSR1 | |
| SCHEMBL13164063 | 0.72 | NPSR1 (0.58) | POLR1AKDM4EHSD17B10NPSR1 | |
| SCHEMBL25970713 | 0.71 | POLR1A (1.00) | POLR1AKCNH2 | |
| SCHEMBL18760971 | 0.69 | NPSR1 (0.54) | POLR1ANPSR1 | |
| SCHEMBL10803261 | 0.69 | SMYD2 (0.54) | POLR1ASMYD2PARP1KDM4ENPSR1 | |
| SCHEMBL25346201 | 0.69 | POLR1A (0.76) | POLR1AHSD17B10KCNH2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079696-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008054956-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2008-05-08 | — | — | WO | disclosed |