Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.64 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.49 |
| ▸ | STK3 | Q13188 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.49 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081562 | 0.90 | PDGFRB (0.63) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4088066 | 0.90 | PDGFRB (0.70) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL1941042 | 0.88 | PDGFRB (0.80) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4083225 | 0.88 | PDGFRB (0.60) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4083193 | 0.88 | PDGFRB (0.64) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4076725 | 0.88 | NTRK1 (0.58) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4086172 | 0.87 | NTRK1 (0.68) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL1941515 | 0.87 | PDGFRB (0.67) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4076606 | 0.87 | PDGFRB (0.62) | PDGFRBNTRK2NTRK1NTRK3AURKA | |
| SCHEMBL4080809 | 0.87 | NTRK1 (0.58) | PDGFRBNTRK2NTRK1NTRK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595325-B2 | Substituted pyrrolo[2,3-d]pyrimidine derivatives useful in cancer treatment | PFIZER INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20060035912-A1 | Pyrrolopyrimidine derivatives useful in cancer treatment | PFIZER INC | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035912-A1 | Pyrrolopyrimidine derivatives useful in cancer treatment | TP53, DPYD, CCNT1 | PDGFRB 2700/4885NTRK2 4246/4885NTRK1 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.