Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106434 | 1.00 | HTR2A (0.47) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4097287 | 1.00 | HTR2A (0.47) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4088908 | 1.00 | HTR2A (0.47) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4091973 | 0.83 | MAPT (0.46) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4091963 | 0.83 | MAPT (0.46) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4091967 | 0.83 | MAPT (0.46) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4098668 | 0.82 | IDO1 (0.49) | HTR2AHTR2BHTR2CIDO1SLC6A4 | |
| SCHEMBL4098666 | 0.82 | IDO1 (0.49) | HTR2AHTR2BHTR2CIDO1SLC6A4 | |
| SCHEMBL4104350 | 0.82 | HTR2A (0.46) | HTR2AMEN1KMT2AHTR2BHTR2C | |
| SCHEMBL4104347 | 0.82 | HTR2A (0.46) | HTR2AMEN1KMT2AHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057119-A1 | 3- (IH-INDOL- 3-YDINDAN-1-YLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | H. Lundbeck A/S (DK) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008025361-A1 | 3-(1H-INDOL-3-YL) INDAN-1-YLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | H. LUNDBECK A/S (DK) | 2008-03-06 | — | — | WO | disclosed |