Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.97 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089251 | 1.00 | HRH3 (0.97) | HRH3CYP2C9KCNH2CYP3A4ACHE | |
| SCHEMBL4088874 | 0.99 | HRH3 (1.00) | HRH3CYP2C9KCNH2CYP3A4ACHE | |
| SCHEMBL4088872 | 0.99 | HRH3 (1.00) | HRH3CYP2C9KCNH2CYP3A4ACHE | |
| SCHEMBL4090293 | 0.86 | HRH3 (0.74) | HRH3CYP2C9KCNH2CYP3A4 | |
| SCHEMBL4090296 | 0.86 | HRH3 (0.74) | HRH3CYP2C9KCNH2CYP3A4 | |
| SCHEMBL4083982 | 0.86 | HRH3 (0.74) | HRH3CYP2C9KCNH2CYP3A4 | |
| SCHEMBL4083984 | 0.86 | HRH3 (0.74) | HRH3CYP2C9KCNH2CYP3A4 | |
| SCHEMBL12050664 | 0.84 | HRH3 (1.00) | HRH3CYP2C9KCNH2CYP3A4 | |
| SCHEMBL4098361 | 0.84 | HRH3 (1.00) | HRH3CYP2C9KCNH2CYP3A4 | |
| SCHEMBL3270562 | 0.83 | HRH3 (0.97) | HRH3CYP2C9KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076329-B2 | Histamine H3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2011-12-13 | — | — | US | claimed |
| US-20090111808-A1 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2009-04-30 | — | — | US | claimed |
| EP-1874746-B1 | DERIVATIVES OF 1-N-AZACYCLOALKYL-3-PHENOXYPROPANE USEFUL FOR THE PREPARATION OF PSYCHOTROPIC MEDICAMENTS | BIOPROJET SOC CIV (FR) | 2015-11-18 | — | — | EP | disclosed |
| US-8076329-B2 | Histamine H3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2011-12-13 | — | — | US | disclosed |
| US-20090312367-A1 | COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR | BIOPROJET (FR) | 2009-12-17 | — | — | US | disclosed |
| US-20090111808-A1 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | BIOPROJET (FR) | 2009-04-30 | — | — | US | disclosed |
| EP-2043624-A2 | COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR | BIOPROJET (FR) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009866-A2 | COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR | BIOPROJET (FR) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111808-A1 | NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | HRH3, HRH4, HRH1 | HRH3 1/4885CYP2C9 1879/4885KCNH2 1031/4885 |
| US-20090312367-A1 | COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR | HRH3, HCRTR2, HCRTR1 | HRH3 1/4885CYP2C9 1708/4885KCNH2 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.