Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884367 | 0.88 | HDAC1 (0.77) | HDAC1LMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL1880667 | 0.81 | HDAC1 (1.00) | HDAC1LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1889591 | 0.79 | HDAC1 (0.79) | HDAC1LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL1891506 | 0.79 | HDAC1 (1.00) | HDAC1SMN1; SMN2 | |
| SCHEMBL1890073 | 0.79 | HDAC1 (0.67) | HDAC1LMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL1884503 | 0.79 | HDAC1 (1.00) | HDAC1 | |
| SCHEMBL1893628 | 0.78 | HDAC1 (0.79) | HDAC1LMNAPOLBALDH1A1MAPT | |
| SCHEMBL3503923 | 0.77 | HDAC1 (0.78) | HDAC1HDAC2 | |
| SCHEMBL12663156 | 0.77 | HDAC1 (0.78) | HDAC1MAPT | |
| SCHEMBL1888025 | 0.76 | HDAC1 (0.74) | HDAC1LMNAHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | claimed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | claimed |