Fexofenadine

Fexofenadine

SCHEMBL40915

CC(C)(C(=O)O)c1ccc([C@@H](O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Fexofenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 6/20 1.00
LMNA P02545 3/20 1.00
DRD3 P35462 3/20 1.00
DRD2 P14416 2/20 1.00
ALOX15 P16050 1/20 1.00
HSD17B10 Q99714 1/20 1.00
KCNH2 Q12809 4/20 0.98
HTR2A P28223 2/20 0.98
HTR2B P41595 2/20 0.98
BLM P54132 2/20 0.98
CNR1 P21554 1/20 0.98
APEX1 P27695 1/20 0.98
PDE4A P27815 1/20 0.98
PDE3A Q14432 1/20 0.98
CYP2J2 P51589 3/20 0.79
MEN1 O00255 1/20 0.79
NPC1 O15118 1/20 0.79
CACNA1F O60840 1/20 0.79
GMNN O75496 1/20 0.79
USP2 O75604 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fexofenadine SCHEMBL29562068 1.00 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL40914 1.00 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL3543634 0.99 HRH1 (0.98) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL1395627 0.99 HRH1 (0.98) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL48729 0.99 HRH1 (0.98) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL1972366 0.99 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL1561082 0.99 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL3178320 0.99 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL4901 0.99 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15
Fexofenadine SCHEMBL4900 0.99 HRH1 (1.00) HRH1LMNADRD3DRD2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6061 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12390416-B2 Chewable pharmaceutical dosage forms USpharma Ltd (US) 2025-08-19 US claimed
CN-118436646-B Application of fexofenadine hydrochloride in preparation of anti-fibrosis drugs 浙江大学 2025-04-15 CN claimed
US-20250082623-A1 COMPOSITIONS CONTAINING FEXOFENADINE OPELLA HEALTHCARE GROUP SAS (FR) 2025-03-13 US claimed
CN-119185198-A Fexofenadine hydrochloride oral suspension and preparation method thereof 杭州泓友医药科技有限公司 2024-12-27 CN claimed
CN-118715004-A Containing fexofenadine fixed composition 欧彼乐医疗集团公司 2024-09-27 CN claimed
CN-118436646-A Application of fexofenadine hydrochloride in preparation of anti-fibrosis drugs 浙江大学 2024-08-06 CN claimed
CN-118425395-A Method for measuring fexofenadine hydrochloride tablet related substances 成都市药品检验研究院 2024-08-02 CN claimed
US-20240226000-A9 TRANSDERMAL PENETRANT FORMULATIONS FOR ADMINISTRATION OF MEDICAMENTS DYVE BIOSCIENCES, INC. 2024-07-11 US claimed
CN-118286163-A Fexofenadine hydrochloride dry suspension and preparation method thereof 桂林华信制药有限公司 2024-07-05 CN claimed
CN-118225926-A Determination method of fexofenadine hydrochloride tablet in-vitro dissolution curve 成都市药品检验研究院 2024-06-21 CN claimed
US-20020151504-A1 STAT modulators TULARIK INC. 2002-10-17 US claimed
WO-2002060411-A2 PROCESS FOR PRODUCTION OF NANOPARTICLES AND MICROPARTICLES BY SPRAY FREEZING INTO LIQUID BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM (US) 2002-08-08 WO claimed
EP-1185266-A4 AMORPHOUS FORM OF FEXOFENADINE HYDROCHLORIDE RANBAXY LAB LTD (IN) 2002-07-17 EP claimed
WO-2002047607-A2 PROCESS FOR THE PREPARATION OF A FAST DISSOLVING DOSAGE FORM RANBAXY LABORATORIES LIMITED (IN) 2002-06-20 WO claimed
WO-2002038107-A2 STAT MODULATORS TULARIK INC. (US) 2002-05-16 WO claimed
EP-1185266-A1 AMORPHOUS FORM OF FEXOFENADINE HYDROCHLORIDE Ranbaxy Laboratories Limited (IN) 2002-03-13 EP claimed
US-20020022639-A1 Packaging regimen of pseudoephedrine hydrochloride and fexofenadine hydrochloride AVENTIS PHARMACEUTICALS INC. 2002-02-21 US claimed
WO-2001085148-A2 PACKAGING REGIMEN OF PSEUDOEPHEDRINE HYDROCHLORIDE AND FEXOFENADINE HYDROCLORIDE AVENTIS PHARMACEUTICALS INC. (US) 2001-11-15 WO claimed
WO-2001083517-A1 STAT4 AND STAT6 BINDING DIPEPTIDE DERIVATIVES TULARIK INC. (US) 2001-11-08 WO claimed
WO-2000071124-A1 AMORPHOUS FORM OF FEXOFENADINE HYDROCHLORIDE RANBAXY LABORATORIES LIMITED (IN) 2000-11-30 WO claimed