Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.60 |
| ▸ | ABL1 | P00519 | 10/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.60 |
| ▸ | BCR | P11274 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30279950 | 1.00 | KDR (0.60) | KDRABL1HDAC3PDGFRBHDAC4 | |
| Hydrochloric Acid SCHEMBL4085037 | 0.98 | KDR (0.58) | KDRABL1HDAC3PDGFRBHDAC4 | |
| SCHEMBL30279956 | 0.81 | KDR (0.57) | KDRABL1HDAC3PDGFRBHDAC4 | |
| SCHEMBL4082500 | 0.81 | KDR (0.57) | KDRABL1HDAC3PDGFRBHDAC4 | |
| Bromide SCHEMBL4082630 | 0.80 | KDR (0.56) | KDRABL1HDAC3PDGFRBHDAC4 | |
| SCHEMBL31290952 | 0.79 | GAA (0.79) | ABL1BCRGAAMEN1KMT2A | |
| SCHEMBL1096303 | 0.79 | GAA (0.79) | ABL1BCRGAAMEN1KMT2A | |
| SCHEMBL22793758 | 0.79 | ABL1 (0.70) | KDRABL1HDAC3PDGFRBHDAC4 | |
| SCHEMBL2924553 | 0.77 | ABL1 (0.64) | KDRABL1PDGFRBBCRGAA | |
| SCHEMBL4263754 | 0.76 | ABL1 (0.60) | KDRABL1HDAC3PDGFRBHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115850258-A | Synthesis method of masitinib | 东北林业大学 | 2023-03-28 | — | — | CN | claimed |
| CN-115850258-A | Synthesis method of masitinib | 东北林业大学 | 2023-03-28 | — | — | CN | disclosed |
| EP-2060565-A1 | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases | 4SC AG (DE) | 2009-05-20 | — | — | EP | disclosed |