Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.44 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.44 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973068 | 0.84 | ERBB2 (0.62) | EGFRERBB2PTK6GRM4AURKA | |
| SCHEMBL2103566 | 0.78 | BCL6 (0.59) | EGFRERBB2GRM4AURKASLK | |
| SCHEMBL5029023 | 0.77 | PTK6 (0.56) | EGFRERBB2PTK6GRM4STK10 | |
| SCHEMBL1096240 | 0.77 | EGFR (1.00) | EGFRERBB2GRM4AURKA | |
| Hydrochloric Acid SCHEMBL4738802 | 0.76 | EGFR (0.98) | EGFRERBB2GRM4AURKA | |
| SCHEMBL16471281 | 0.76 | GRM4 (0.57) | EGFRERBB2PTK6GRM4MAPT | |
| SCHEMBL4191612 | 0.75 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL4714696 | 0.75 | BCL6 (0.50) | EGFRAURKASLKMAPTBLM | |
| SCHEMBL3321550 | 0.74 | EGFR (0.46) | EGFRERBB2PTK6GRM4STK10 | |
| SCHEMBL3975050 | 0.74 | EGFR (0.62) | EGFRERBB2PTK6GRM4STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055299-A1 | SUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE AND 5-CARBOXYLIC ESTER KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | WO | disclosed |