Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | CCNK | O75909 | 3/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.47 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | CIT | O14578 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99955 | 0.91 | CCNK (0.56) | ROCK2ROCK1CCNKCDK12AURKA | |
| SCHEMBL29540648 | 0.91 | CCNK (0.56) | ROCK2ROCK1CCNKCDK12AURKA | |
| Trifluoroacetic Acid SCHEMBL4082781 | 0.86 | JAK1 (0.55) | ROCK1CCNKCDK12AURKAAURKB | |
| Trifluoroacetic Acid SCHEMBL4086708 | 0.85 | JAK1 (0.46) | ROCK2ROCK1CCNKCDK12AURKA | |
| Trifluoroacetic Acid SCHEMBL4082598 | 0.84 | JAK1 (0.50) | ROCK1CCNKCDK12AURKAAURKB | |
| Trifluoroacetic Acid SCHEMBL4088813 | 0.84 | CCNK (0.56) | ROCK1CCNKCDK12AURKAAURKB | |
| Trifluoroacetic Acid SCHEMBL4088103 | 0.83 | JAK1 (0.47) | ROCK1CCNKCDK12AURKAAURKB | |
| Trifluoroacetic Acid SCHEMBL4092253 | 0.82 | ALK (0.55) | ROCK2ROCK1CCNKCDK12AURKA | |
| Trifluoroacetic Acid SCHEMBL4095963 | 0.81 | JAK1 (0.46) | CCNKCDK12AURKAAURKBINCENP | |
| Trifluoroacetic Acid SCHEMBL4088053 | 0.81 | ALK (0.55) | CCNKCDK12AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130137681-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2013-05-30 | — | — | US | disclosed |
| US-8415362-B2 | Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2013-04-09 | — | — | US | disclosed |
| US-20090181959-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137681-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | ROCK2 1189/4885ROCK1 1782/4885CCNK 374/4885 |
| US-20090181959-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | ROCK2 1189/4885ROCK1 1782/4885CCNK 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.