Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.43 |
| ▸ | JAK1 | P23458 | 16/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.42 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CIT | O14578 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ULK1 | O75385 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | MARK3 | P27448 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99314 | 0.86 | JAK2 (0.46) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL29540514 | 0.86 | JAK2 (0.46) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL102145 | 0.86 | JAK2 (0.46) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL169693 | 0.86 | JAK2 (0.46) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL100331 | 0.84 | JAK2 (0.51) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL99796 | 0.84 | JAK2 (0.51) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL29540612 | 0.84 | JAK2 (0.51) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL171724 | 0.84 | JAK2 (0.51) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL29541122 | 0.83 | JAK2 (0.42) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL171407 | 0.83 | JAK2 (0.46) | JAK2JAK1JAK3TYK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181959-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-07-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181959-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885JAK3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.