Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 7/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.35 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4101819 | 0.87 | SMN1; SMN2 (0.48) | TP53SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL13871099 | 0.86 | USP30 (0.41) | HCRTR1HCRTR2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL4095643 | 0.84 | HCRTR1 (0.36) | HCRTR1HCRTR2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL4095640 | 0.84 | HCRTR1 (0.36) | HCRTR1HCRTR2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL4103687 | 0.84 | MAOB (0.41) | HCRTR1HCRTR2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL8038357 | 0.83 | HCRTR1 (0.35) | HCRTR1HCRTR2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL4229285 | 0.77 | NPC1 (0.32) | HCRTR1HCRTR2ALDH1A1HPGDNPC1 | |
| SCHEMBL13871093 | 0.75 | USP30 (0.50) | TP53SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4107748 | 0.73 | SMN1; SMN2 (0.43) | TP53SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4107744 | 0.73 | SMN1; SMN2 (0.43) | TP53SMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111820-A1 | FUSED PYRROLIDINE 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | claimed |
| US-20090111820-A1 | FUSED PYRROLIDINE 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111820-A1 | FUSED PYRROLIDINE 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 | GRM5, GRIK5, GRM1 | HCRTR1 816/4885HCRTR2 386/4885TP53 4876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.