Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098801 | 1.00 | EGFR (0.46) | EGFRPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL2717866 | 0.84 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBBCL2 | |
| SCHEMBL15437195 | 0.84 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBBCL2 | |
| SCHEMBL4100816 | 0.84 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBBCL2 | |
| SCHEMBL2718225 | 0.83 | PIK3CD (0.49) | EGFRPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL2731870 | 0.83 | PIK3CD (0.49) | EGFRPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL2720488 | 0.83 | PIK3CD (0.49) | EGFRPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL4097174 | 0.78 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBBCL2 | |
| SCHEMBL2717249 | 0.78 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBBCL2 | |
| SCHEMBL2719996 | 0.78 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |