Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BM
The experimentally established mechanism targets of Amantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 6/20 | 1.00 |
| ▸ | GRIN2A known ✓ | Q12879 | 6/20 | 1.00 |
| ▸ | GRIN2D known ✓ | O15399 | 5/20 | 1.00 |
| ▸ | GRIN3B known ✓ | O60391 | 5/20 | 1.00 |
| ▸ | GRIN2B known ✓ | Q13224 | 5/20 | 1.00 |
| ▸ | GRIN2C known ✓ | Q14957 | 5/20 | 1.00 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 2/20 | 1.00 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | STAT6 | P42226 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 0.93 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.93 |
| ▸ | POLB | P06746 | 1/20 | 0.93 |
| ▸ | BLM | P54132 | 1/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amantadine SCHEMBL20409394 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL15672299 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21309814 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL15532073 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL3642447 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21310017 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL23859927 | 0.96 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL8996708 | 0.96 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL17559292 | 0.96 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL5569374 | 0.96 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 78764 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-121591614-B | Adamantane derivative and synthesis method and application thereof | Shandong Xinhua Pharmaceutical Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026106939-A1 | IMPROVING SYMPTOMS IN MID- TO LATE-STAGE PARKINSON'S DISEASE PATIENTS USING WITH DEEP BRAIN STIMULATION | VANDERBILT UNIVERSITY (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| EP-4094767-B1 | NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO | UNIV EMORY (US) | 2026-05-20 | — | — | EP | claimed |
| EP-4742891-A2 | METHOD OF GENOME-EDITING | Universiteit Gent (BE) | 2026-05-20 | — | — | EP | claimed |
| CN-121250719-B | Preparation method of bio-based fluorine-free high-barrier food packaging paper | 浙江凯丰新材料股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-12630593-B2 | Method of killing leukemia cells by administration of recombinant'Y3 proteins | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2026-05-19 | — | — | US | claimed |
| CN-122036494-A | Synthesis method and application of amantadine-butylphthalide eutectic | 佛山大学 | 2026-05-15 | — | — | CN | claimed |
| US-4156087-A | OXYTOCICS, ANTIULCER AGENTS | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | claimed |
| US-4151351-A | PROSTAGLANDINS, ANTIINFLAMMATORY | THE UPJOHN COMPANY (US) | 1979-04-24 | — | — | US | claimed |
| US-4148896-A | AMANTADINE AND MOLINDONE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-04-10 | — | — | US | claimed |
| US-4145535-A | Pyran analogs of trans-4,5-didehydro-PGI compounds | THE UPJOHN COMPANY (US) | 1979-03-20 | — | — | US | claimed |
| US-4128713-A | 6,7-Didehydro-PGI1 compounds | THE UPJOHN COMPANY (US) | 1978-12-05 | — | — | US | claimed |
| US-4126744-A | PROSTACYCLIN, MUSCLE STIMULANTS, PLATELET AGGREGATION INHIBITORS | THE UPJOHN COMPANY (US) | 1978-11-21 | — | — | US | claimed |
| US-4110532-A | PROSTAGLANDINS, SMOOTH MUSCLE STIMULANTS | THE UPJOHN COMPANY (US) | 1978-08-29 | — | — | US | claimed |
| US-4109082-A | PROSTACYCLIN ANALOGS; SMOOTH MUSCLE STIMULATORS | THE UPJOHN COMPANY (US) | 1978-08-22 | — | — | US | claimed |
| US-3962308-A | Process for converting esters to amine salts | THE UPJOHN COMPANY (US) | 1976-06-08 | — | — | US | claimed |
| US-3941885-A | N-ADAMANTANYL AMINO ALKANOIC ACID | SCHERING CORPORATION (US) | 1976-03-02 | — | — | US | claimed |