Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14893851 | 0.85 | TNF (0.42) | PKN1PKN2TNFKDM4EHTT | |
| SCHEMBL14893839 | 0.81 | HASPIN (0.47) | TNFKMT2AKDM4EHTTMAPT | |
| SCHEMBL30937994 | 0.81 | HASPIN (0.47) | TNFKMT2AKDM4EHTTMAPT | |
| SCHEMBL2223329 | 0.80 | NR4A1 (0.60) | TNFMEN1KMT2AKDM4EHTT | |
| SCHEMBL31522172 | 0.80 | NR4A1 (0.60) | TNFMEN1KMT2AKDM4EHTT | |
| SCHEMBL10407111 | 0.79 | NR4A1 (0.59) | MEN1KMT2ASMN1; SMN2POLBKDM4E | |
| SCHEMBL29715203 | 0.78 | KDM4E (0.59) | PKN1PKN2TNFKMT2ASMN1; SMN2 | |
| SCHEMBL28892310 | 0.78 | TNF (0.46) | TNFKMT2ASMN1; SMN2KDM4EHTT | |
| Hydrochloric Acid SCHEMBL29816682 | 0.78 | NR4A1 (0.58) | TNFMEN1KMT2AKDM4EHTT | |
| SCHEMBL30771576 | 0.78 | NR4A1 (0.58) | TNFMEN1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024342-A2 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | Pfizer Products Incorporated (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007125405-A2 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-08 | — | — | WO | disclosed |