Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.84 |
| ▸ | PIM1 | P11309 | 1/20 | 0.84 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.84 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.61 |
| ▸ | PPARA | Q07869 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10026584 | 0.92 | CHEK1 (1.00) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL13870836 | 0.90 | CHEK1 (0.67) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL13870844 | 0.88 | CHEK1 (0.65) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL4097163 | 0.87 | KCNK9 (0.72) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL14855642 | 0.85 | KMT2A (0.79) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL26808968 | 0.83 | KMT2A (0.68) | ALDH1A1MEN1KMT2AHTTPOLB | |
| SCHEMBL4141962 | 0.82 | MEN1 (0.89) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL4669123 | 0.82 | CHEK1 (0.81) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL4670317 | 0.82 | CHEK1 (0.81) | CHEK1PIM1MAPK8CLK4ALDH1A1 | |
| SCHEMBL13870852 | 0.82 | KMT2A (0.69) | CHEK1PIM1MAPK8CLK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105218-A1 | CRTH2 Receptor Ligands For Therapeutic Use | 7TM PHARMA A/S (DK) | 2009-04-23 | — | — | US | disclosed |
| US-20090105218-A1 | CRTH2 Receptor Ligands For Therapeutic Use | 7TM PHARMA A/S (DK) | 2009-04-23 | — | — | US | disclosed |
| US-20090105218-A1 | CRTH2 Receptor Ligands For Therapeutic Use | 7TM PHARMA A/S (DK) | 2009-04-23 | — | — | US | disclosed |
| EP-1758571-A1 | CRTH2 RECEPTOR LIGANDS FOR THERAPEUTIC USE | 7TM Pharma A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005115374-A1 | CRTH2 RECEPTOR LIGANDS FOR THERAPEUTIC USE | 7TM PHARMA A/S (DK) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105218-A1 | CRTH2 Receptor Ligands For Therapeutic Use | NR1H2, NR1H3, HRH2 | CHEK1 3565/4885PIM1 3168/4885MAPK8 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.