Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.78 |
| ▸ | TBXA2R | P21731 | 12/20 | 0.69 |
| ▸ | PTGDR | Q13258 | 12/20 | 0.69 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.69 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.69 |
| ▸ | PTGIR | P43119 | 3/20 | 0.69 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.69 |
| ▸ | PTGFR | P43088 | 2/20 | 0.69 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | TSPO | P30536 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408220 | 0.88 | PDE2A (1.00) | PDE2ATBXA2RPTGDRPTGER3PTGER2 | |
| SCHEMBL9518093 | 0.85 | TBXA2R (0.77) | PDE2ATBXA2RPTGDRPTGER3PTGER2 | |
| SCHEMBL9518262 | 0.85 | TBXA2R (0.57) | PDE2ATBXA2RPTGDR | |
| SCHEMBL10413596 | 0.83 | TBXA2R (0.74) | PDE2ATBXA2RPTGDRPTGER3PTGER2 | |
| SCHEMBL9518207 | 0.83 | TBXA2R (0.62) | PDE2ATBXA2RPTGDR | |
| SCHEMBL12923707 | 0.82 | PTGDR (0.80) | TBXA2RPTGDRPTGER3PTGER2PTGIR | |
| SCHEMBL9518211 | 0.82 | TBXA2R (0.65) | PDE2ATBXA2RPTGDR | |
| SCHEMBL4100109 | 0.82 | PTGDR (1.00) | PDE2ATBXA2RPTGDRPTGER3PTGER2 | |
| SCHEMBL1254353 | 0.82 | PTGDR (1.00) | PDE2ATBXA2RPTGDRPTGER3PTGER2 | |
| SCHEMBL9519473 | 0.82 | TBXA2R (0.61) | PDE2ATBXA2RPTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115921-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115921-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20100081696-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | BERTHELETTE CARL | 2010-04-01 | — | — | US | disclosed |
| US-7618994-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |
| US-7618994-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |
| US-20080033028-A1 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | BERTHELETTE CARL | 2008-02-07 | — | — | US | disclosed |
| US-20080033028-A1 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | BERTHELETTE CARL | 2008-02-07 | — | — | US | disclosed |
| US-7317036-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA & CO. (CA) | 2008-01-08 | — | — | US | disclosed |
| US-7317036-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA & CO. (CA) | 2008-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115921-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | PTGER1, PTGER3, PTGER2 | PDE2A 463/4885TBXA2R 17/4885PTGDR 7/4885 |
| US-20080033028-A1 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | PTGER1, PTGER3, PTGER2 | PDE2A 463/4885TBXA2R 17/4885PTGDR 7/4885 |
| US-20100081696-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | PTGER1, PTGER3, PTGER2 | PDE2A 463/4885TBXA2R 17/4885PTGDR 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.