Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27897862 | 0.90 | AURKA (0.47) | ADORA2AAURKAHSP90AA1PRKACASREBF2 | |
| SCHEMBL10272516 | 0.85 | AURKA (0.53) | ADORA2AAURKAHSP90AA1PRKACASREBF2 | |
| SCHEMBL27689688 | 0.82 | AURKA (0.50) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL28172767 | 0.82 | AURKA (0.50) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL17261523 | 0.82 | AURKA (0.55) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL28144689 | 0.78 | HSP90AA1 (0.46) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL8703546 | 0.78 | AURKA (0.53) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL1514690 | 0.78 | HSP90AA1 (0.58) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL28145717 | 0.78 | HSP90AA1 (0.53) | ADORA2AAURKAHSP90AA1PRKACAKDM4E | |
| SCHEMBL3970473 | 0.78 | AURKA (0.53) | ADORA2AAURKAHSP90AA1PRKACAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008030369-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |