Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108271 | 1.00 | KCNH2 (0.60) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4108266 | 1.00 | KCNH2 (0.60) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4102255 | 1.00 | KCNH2 (0.60) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4114880 | 0.92 | KCNH2 (0.70) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4113439 | 0.92 | KCNH2 (0.70) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4114882 | 0.92 | KCNH2 (0.70) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4113432 | 0.92 | KCNH2 (0.70) | KCNH2PIP4K2APIP4K2BCHRNA7HRH3 | |
| SCHEMBL4109790 | 0.87 | KCNH2 (0.48) | KCNH2PIP4K2APIP4K2BCHRNA7 | |
| SCHEMBL4114266 | 0.83 | KCNH2 (0.56) | KCNH2CHRNA7CHRNB4CHRNA3 | |
| SCHEMBL4114261 | 0.83 | KCNH2 (0.56) | KCNH2CHRNA7CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604611-A1 | N-Biaryl substituted diazabicycloalkane derivatives as agonists of the alpha7 and alpha4beta2 nACh Receptor | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | claimed |
| US-20090197860-A1 | BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-08-06 | — | — | US | claimed |
| EP-2231672-B1 | BIARYL SUBSTITUTED DIAZABICYCLOHEPTANE DERIVATIVES AS nAChR MODULATORS | ABBVIE INC (US) | 2014-12-17 | — | — | EP | disclosed |
| EP-2604611-A1 | N-Biaryl substituted diazabicycloalkane derivatives as agonists of the alpha7 and alpha4beta2 nACh Receptor | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20090197860-A1 | BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197860-A1 | BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES | BRCA1, VHL, AADAC | KCNH2 2724/4885PIP4K2A 796/4885PIP4K2B 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.