Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 18/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102602 | 0.98 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1362290 | 0.95 | CHRM3 (0.51) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4095075 | 0.95 | PDE4B (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1364580 | 0.94 | CHRM3 (0.53) | CHRM3CHRM2CHRM1KCNH2 | |
| SCHEMBL4087829 | 0.94 | PDE4B (0.46) | CHRM3CHRM2CHRM1PDE4B | |
| SCHEMBL4087812 | 0.94 | PDE4B (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL3431618 | 0.94 | PDE4B (0.46) | CHRM3CHRM2CHRM1PDE4B | |
| SCHEMBL4360458 | 0.94 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4350953 | 0.94 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL3432201 | 0.94 | PDE4B (0.49) | CHRM3PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084449-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-12-27 | — | — | US | claimed |
| US-20090203657-A1 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | US | claimed |
| US-8084449-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-12-27 | — | — | US | disclosed |
| US-20090203657-A1 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203657-A1 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics | PDE4A, PDE1A, PDE4B | CHRM3 8/4885CHRM2 7/4885CHRM1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.