Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 8/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.70 |
| ▸ | MITF | O75030 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 12/20 | 0.67 |
| ▸ | MEN1 | O00255 | 10/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GBA1 | P04062 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104631 | 0.90 | KMT2A (0.59) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 | |
| SCHEMBL4106089 | 0.89 | MEN1 (0.60) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 | |
| SCHEMBL4107028 | 0.87 | SMN1; SMN2 (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 | |
| SCHEMBL4111978 | 0.87 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2PAX8MITF | |
| SCHEMBL4113061 | 0.85 | MAPT (0.73) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 | |
| SCHEMBL405087 | 0.85 | NPC1 (0.69) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4121731 | 0.84 | MAPT (0.72) | NPC1RAB9ASMN1; SMN2PAX8MITF | |
| SCHEMBL4104467 | 0.84 | MAPT (0.76) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 | |
| SCHEMBL4112399 | 0.83 | MEN1 (0.76) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 | |
| SCHEMBL10576308 | 0.83 | MAPT (0.86) | ALDH1A1NPC1RAB9ASMN1; SMN2PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | claimed |
| EP-1804785-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006049941-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | WO | claimed |
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | disclosed |
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | disclosed |
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | NEUROGEN CORPORATION | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239841-A1 | Diaryl Ureas as CB1 Antagonists | CNR1, CNR2, OPRL1 | ALDH1A1 994/4885NPC1 927/4885RAB9A 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.