Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27684091 | 1.00 | CA1 (0.56) | CA1CA2CA9ACHEFFAR3 | |
| Bicarbonate SCHEMBL18862892 | 1.00 | — | — | |
| Bicarbonate SCHEMBL18862893 | 1.00 | CA1 (0.56) | CA1CA2CA9ACHEFFAR3 | |
| Bicarbonate SCHEMBL8009116 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5557762 | 0.94 | — | — | |
| Bicarbonate SCHEMBL14563795 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5015541 | 0.94 | — | — | |
| Bicarbonate SCHEMBL14881195 | 0.94 | CA1 (0.62) | CA1CA2CA9ACHEFFAR3 | |
| Bicarbonate SCHEMBL81418 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28460247 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009513512-A | — | — | 2009-04-02 | — | — | JP | claimed |
| US-20050038018-A1 | Mixture with antacids, sedatives; central nervous system stimulants; antiinflammatory agents; analgesics | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-02-17 | — | — | US | claimed |
| WO-2005004915-A2 | COMPOSITIONS COMPRISING MELOXICAM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-01-20 | — | — | WO | claimed |
| US-6555137-B1 | For delayed release of an antacid in the stomach containing a coated antacid | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-04-29 | — | — | US | claimed |
| EP-1000614-A1 | SUCRALFATE-CONTAINING COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-05-17 | — | — | EP | claimed |
| CN-117467166-A | Method for inhibiting accumulation | 旭化成株式会社 | 2024-01-30 | — | — | CN | disclosed |
| CN-112585192-B | Cellulose powder, use thereof and tablets | 旭化成株式会社 | 2023-11-21 | — | — | CN | disclosed |
| CN-116406260-A | Solid preparation containing ibuprofen | SS制药株式会社 | 2023-07-07 | — | — | CN | disclosed |
| EP-3880171-B1 | IBUPROFEN-CONTAINING ORAL PHARMACEUTICAL FORMULATION | SSP CO LTD (JP) | 2023-06-07 | — | — | EP | disclosed |
| EP-3385306-B1 | COMPOSITE PARTICLES INCLUDING CELLULOSE, INORGANIC COMPOUND, AND HYDROXYPROPYL CELLULOSE | ASAHI CHEMICAL IND (JP) | 2023-01-25 | — | — | EP | disclosed |
| WO-2022114240-A1 | SOLID PREPARATION CONTAINING IBUPROFEN | SSP CO., LTD. (JP) | 2022-06-02 | — | — | WO | disclosed |
| EP-3989945-A1 | MELOXICAM-CONTAINING GRANULATED PRODUCT | SSP Co., Ltd. (JP) | 2022-05-04 | — | — | EP | disclosed |
| US-20030069213-A1 | ORAL PREPARATION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-04-10 | — | — | US | disclosed |
| CN-1280506-A | Oral Preparation | DAIICHI SEIYAKU CO (JP) | 2001-01-17 | — | — | CN | disclosed |
| EP-1020193-A1 | ORAL PREPARATION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
| EP-1000614-A1 | SUCRALFATE-CONTAINING COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-05-17 | — | — | EP | disclosed |
| CN-1243004-A | Enterogastric medicine for resisting activity of pyloric twining bacillus | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-02-02 | — | — | CN | disclosed |
| US-5294439-A | Stabilized benzimidazole derivative and composition | NIPPON CHEMIPHAR CO., LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0248634-B1 | STABILIZED BENZIMIDAZOLE DERIVATIVE AND COMPOSITION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |
| EP-0248634-A2 | Stabilized benzimidazole derivative and composition | NIPPON CHEMIPHAR CO., LTD. (JP) | 1987-12-09 | — | — | EP | disclosed |