Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotaxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.86 |
| ▸ | PPARG | P37231 | 2/20 | 0.86 |
| ▸ | ALB | P02768 | 1/20 | 0.86 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.86 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.86 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.86 |
| ▸ | ESR1 | P03372 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotaxime SCHEMBL537163 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL10486930 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL9075627 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL29615351 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL9491367 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL10569095 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL29761224 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| Cefotaxime SCHEMBL10486935 | 1.00 | TDP1 (1.00) | TDP1MAPTHSD17B10APEX1POLB | |
| SCHEMBL9076385 | 0.94 | TDP1 (0.89) | TDP1MAPTHSD17B10APEX1POLB | |
| SCHEMBL9076379 | 0.94 | TDP1 (0.89) | TDP1MAPTHSD17B10APEX1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5656 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122060783-A | Construction method of agrobacterium rhizogenes-mediated acacia jequirity genetic transformation system | 中国林业科学研究院热带林业研究所 | 2026-05-19 | — | — | CN | claimed |
| CN-122060786-A | Visual genetic transformation method of Chinese tallow tree mediated by RUBY reporter gene | 中国科学院合肥物质科学研究院 | 2026-05-19 | — | — | CN | claimed |
| CN-120131568-A | Cefotaxime sodium preparation for injection and preparation method thereof | 成都晶富医药科技有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120079414-A | Ternary composite material and preparation method and application thereof | 湖南工业大学 | 2025-06-03 | — | — | CN | claimed |
| WO-2025111413-A1 | TREATMENT FOR SKIN DISORDERS | Mycotechnology, Inc. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119950812-A | Bacterial response type static direct-writing composite patch and preparation method thereof | 东华大学 | 2025-05-09 | — | — | CN | claimed |
| CN-113005175-B | Total bile acid detection kit and method | 深圳迈瑞生物医疗电子股份有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119866929-A | Rapid propagation method of orchid seedlings and application thereof | 佛山市农业科学研究所(佛山市农业技术推广中心) | 2025-04-25 | — | — | CN | claimed |
| CN-116076504-B | Bacteriostat, culture medium and open tissue culture method for populus seedlings | 辽宁省杨树研究所 | 2025-04-25 | — | — | CN | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| WO-2002030469-A2 | BETA-LACTAM ANTIBIOTIC-POLYSACCHARIDE COMPLEX | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2002-04-18 | — | — | WO | claimed |
| WO-2002002080-A1 | RAPID-MELT SEMI-SOLID COMPOSITIONS, METHODS OF MAKING SAME AND METHODS OF USING SAME | CAPRICORN PHARMA, INC. (US) | 2002-01-10 | — | — | WO | claimed |
| US-20020004071-A1 | Rapid-melt semi-solid compositions, methods of making same and methods of using same | CAPRICORN PHARMA, INC. | 2002-01-10 | — | — | US | claimed |
| US-6245735-B1 | CONJUGATE OF ANTIBIOTIC AND POLYPEPTIDE OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR OR LIPOPOLYSACCHARIDE BINDING FRAGMENT | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2001-06-12 | — | — | US | claimed |
| US-5831086-A | Production of cefotaxime and new sodium salts | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1998-11-03 | — | — | US | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0522139-A1 | TISSUE CRYOPRESERVATION METHOD | CRYOLIFE, INC (US) | 1993-01-13 | — | — | EP | claimed |
| WO-1992012632-A1 | TISSUE CRYOPRESERVATION METHOD | CRYOLIFE, INC. (US) | 1992-08-06 | — | — | WO | claimed |
| WO-1992012631-A1 | TISSUE CRYOPRESERVATION METHOD | CRYOLIFE, INC. (US) | 1992-08-06 | — | — | WO | claimed |
| CN-1034670-A | The stable composition that cephalosporins derivatives and the common drying of a kind of stabilizing agent are made the stable method of this derivant and contain cephalosporins derivatives | HOECHST AG (DE) | 1989-08-16 | — | — | CN | claimed |