Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefdinir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 2/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 0.79 |
| ▸ | APAF1 | O14727 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.79 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.79 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.79 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.78 |
| ▸ | MMP2 | P08253 | 1/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 2/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefdinir SCHEMBL3299566 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL36995 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL6820723 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL2221924 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL5919457 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL3297328 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL16072816 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL1559599 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL36996 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 | |
| Cefdinir SCHEMBL4114437 | 1.00 | TDP1 (1.00) | TDP1MAPTABCC4CNR1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749013-A2 | STABLE AMORPHOUS CEFDINIR | ABBOTT LABORATORIES (US) | 2007-02-07 | — | — | EP | claimed |
| US-20060122165-A1 | Crystalline cefdinir | DAEMON OTTO | 2006-06-08 | — | — | US | claimed |
| US-20060069079-A1 | Stable amorphous cefdinir | ABBOTT LABORATORIES | 2006-03-30 | — | — | US | claimed |
| US-20060029674-A1 | Stable amorphous Cefdinir | ABBOTT LABORATORIES | 2006-02-09 | — | — | US | claimed |
| WO-2006010978-A1 | CEFDINIR POLYMORPHIC FORMS, AND IMIDAZOLE SALT | WOCKHARDT LIMITED (IN) | 2006-02-02 | — | — | WO | claimed |
| WO-2005100368-A2 | STABLE AMORPHOUS CEFDINIR | ABBOTT LABORATORIES (US) | 2005-10-27 | — | — | WO | claimed |
| EP-0304019-B1 | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-31 | — | — | EP | claimed |
| US-4935507-A | Cefdinir antibiotic | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-06-19 | — | — | US | claimed |
| EP-0105459-B1 | SYN-ISOMER OF 7-SUBSTITUTED-3-VINYL-3-CEPHEM COMPOUNDS, PROCESSES FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-03-22 | — | — | EP | claimed |
| EP-0304019-A2 | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-02-22 | — | — | EP | claimed |
| US-4559334-A | MICROBIOCIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-12-17 | — | — | US | claimed |
| EP-0105459-A2 | Syn-isomer of 7-substituted-3-vinyl-3-cephem compounds, processes for production thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-04-18 | — | — | EP | claimed |
| JP-1250384-A | — | — | None | — | — | JP | disclosed |
| JP-1250384-A | — | — | None | — | — | JP | disclosed |
| JP-59089689-A | — | — | None | — | — | JP | disclosed |
| EP-1795197-B1 | Pharmaceutical compositions comprising an antibiotic | SANDOZ AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-0304019-A2 | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-02-22 | — | — | EP | disclosed |
| US-4559334-A | MICROBIOCIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-12-17 | — | — | US | disclosed |
| JP-S5989689-A | 7-SUBSTITUTED-3-VINYL-3-CEPHEM COMPOUND, ITS PRODUCTION AND ANTIMICROBIAL AGENT CONTAINING THE SAME | FUJISAWA PHARMACEUT CO LTD | 1984-05-23 | — | — | JP | disclosed |
| EP-0105459-A2 | Syn-isomer of 7-substituted-3-vinyl-3-cephem compounds, processes for production thereof and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-04-18 | — | — | EP | disclosed |