Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4111781 | 0.93 | PIK3CA (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10327749 | 0.91 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL4107914 | 0.90 | PIK3CA (0.52) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10328100 | 0.90 | PIK3CA (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10328099 | 0.85 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10327896 | 0.84 | PIK3CA (0.70) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL13848004 | 0.83 | PIK3CA (0.70) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10327786 | 0.82 | PIK3CA (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10327601 | 0.82 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL10327854 | 0.82 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | claimed |
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |