Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4116320 | 1.00 | CNR2 (0.45) | CNR2PDE4BPDE4DSLC10A1PDE4A | |
| SCHEMBL4115372 | 0.94 | CNR2 (0.44) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4115370 | 0.94 | CNR2 (0.44) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4117356 | 0.93 | CNR2 (0.43) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4117350 | 0.93 | CNR2 (0.43) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4113668 | 0.88 | CNR2 (0.41) | CNR2 | |
| SCHEMBL4113665 | 0.88 | CNR2 (0.41) | CNR2 | |
| SCHEMBL4117186 | 0.82 | CNR2 (0.48) | CNR2PDE4BPDE4DSLC10A1PDE4A | |
| SCHEMBL1175131 | 0.82 | CNR2 (0.54) | CNR2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4117191 | 0.82 | CNR2 (0.48) | CNR2PDE4BPDE4DSLC10A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | claimed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | CNR2 2/4885PDE4B 3700/4885PDE4D 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.