Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132102 | 0.87 | KDM4E (0.39) | KDM4EKMT2ANPSR1GAAPOLB | |
| SCHEMBL4133173 | 0.84 | KDM4E (0.60) | KDM4EKMT2ANPSR1GAAPOLB | |
| SCHEMBL4131302 | 0.83 | KDM4E (0.38) | KDM4EKMT2ANPSR1GAAPOLB | |
| SCHEMBL4126264 | 0.82 | KDM4E (0.39) | KDM4EKMT2ANPSR1GAAPOLB | |
| Hydrochloric Acid SCHEMBL4131296 | 0.82 | KDM4E (0.38) | KDM4EKMT2ANPSR1GAAPOLB | |
| SCHEMBL4127123 | 0.82 | KDM4E (0.38) | KDM4EKMT2ANPSR1GAAPOLB | |
| Hydrochloric Acid SCHEMBL4126261 | 0.81 | KDM4E (0.39) | KDM4EKMT2ANPSR1GAAPOLB | |
| Hydrochloric Acid SCHEMBL4127118 | 0.81 | KDM4E (0.37) | KDM4EKMT2ANPSR1GAAPOLB | |
| SCHEMBL4121055 | 0.81 | KDM4E (0.40) | KDM4EKMT2ANPSR1GAAPOLB | |
| Hydrochloric Acid SCHEMBL4121051 | 0.81 | KDM4E (0.39) | KDM4EKMT2ANPSR1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | KDM4E 899/4885KMT2A 2936/4885NPSR1 3948/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | KDM4E 899/4885KMT2A 2936/4885NPSR1 3948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.